Research interests
My recent work has focused on studying an autism spectrum disorder associated with a novel mutation in pyruvate dehydrogenase (PDH). An undescribed point mutation in a mitochondrial protein associated with severe autism will be studied. The minimal objective is to analyze parameters of energy metabolism and stress in cell cultures of these patients. Based on what they observe, they will test treatments to rescue the functional deficits associated with the PDH mutation.
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Academic background
2023-present
Postdoctoral researcher
Posdoctoral researcher
Instituto de Investigación Médica Martín y Mercedes Ferreyra, Cordoba, Argentina
I´m working on the role of chromosome imbalance in energetic metabolism and cellular senescence.
2016-2022
Ph.D
Ph.D in Neuroscience
National University of Cordoba, Argentina
During my thesis I studied the circadian rhythms of epigenetic modifications in genes related to cognitive functions in an aging model subjected to caloric restriction.
2006-2015
Bachelor's Degree
B.Sc. in Molecular Biology
National University of San Luis, Argentina
As part of my thesis I studied the modification of the circadian rhythmicity of the antioxidant defense system in the heart during aging in male rats.
Publications
Altamirano, F. G., Castro-Pascual, I. C., Ferramola, M. L., Tula, M. L., Delgado, S. M., Anzulovich, A. C., & Lacoste, M. G. (2021). Aging disrupts the temporal organization of antioxidant defenses in the heart of male rats and phase shifts circadian rhythms of systolic blood pressure. Biogerontology, 22(6), 603–621. Advance online publication.
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